Pancreatic β cells: Gatekeepers of type 2 diabetes

J Cell Biol. 2019 Apr 1;218(4):1094-1095. doi: 10.1083/jcb.201810097. Epub 2019 Jan 29.

Abstract

Park and Woo outline the cellular events leading to failure of the insulin-producing β cells in type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Autophagy
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / pathology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Inflammation Mediators / metabolism
  • Insulin / blood
  • Insulin / metabolism*
  • Insulin Resistance*
  • Insulin-Secreting Cells / drug effects
  • Insulin-Secreting Cells / metabolism*
  • Insulin-Secreting Cells / pathology
  • Necrosis
  • Signal Transduction

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Inflammation Mediators
  • Insulin

Grants and funding