Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives

Jianwei Chen; Bixia Wang; Yaojia Lu; Yuqi Guo; Jiadong Sun; Bin Wei; Huawei Zhang; Hong Wang

doi:10.3390/md17020080

Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives

Mar Drugs. 2019 Jan 28;17(2):80. doi: 10.3390/md17020080.

Authors

Jianwei Chen¹, Bixia Wang², Yaojia Lu³, Yuqi Guo⁴, Jiadong Sun⁵, Bin Wei⁶, Huawei Zhang⁷, Hong Wang⁸

Affiliations

¹ College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. cjw983617@zjut.edu.cn.
² College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. 15757116051@163.com.
³ College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. lyj512637@zjut.edu.cn.
⁴ College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. m17816038135_1@163.com.
⁵ Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20878, USA. jiadong.sun@nih.gov.
⁶ College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. binwei@zjut.edu.cn.
⁷ College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. hwzhang@zjut.edu.cn.
⁸ College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. hongw@zjut.edu.cn.

Abstract

Quorum sensing inhibitors (QSIs) present a promising alternative or potent adjuvants of conventional antibiotics for the treatment of antibiotic-resistant bacterial strains, since they could disrupt bacterial pathogenicity without imposing selective pressure involved in antibacterial treatments. This review covers a series of molecules showing quorum sensing (QS) inhibitory activity that are isolated from marine microorganisms, including bacteria, actinomycetes and fungi, and chemically synthesized based on QSIs derived from marine microorganisms. This is the first comprehensive overview of QSIs derived from marine microorganisms and their synthetic analogues with QS inhibitory activity.

Keywords: derivatives; marine microorganism; quorum sensing; quorum sensing inhibitor.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / pharmacology*
Aquatic Organisms*
Bacteria / drug effects*
Bacteria / metabolism
Drug Resistance, Bacterial*
Fungi / metabolism*
Quorum Sensing / drug effects*

Substances

Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding