Screening of NogoA/NTR-related differential genes in rat sciatic nerve injury signal pathway

Per Med. 2019 Mar;16(2):93-105. doi: 10.2217/pme-2018-0088. Epub 2019 Jan 29.

Abstract

Aim: To screen the differential genes in NogoA/NTR-related pathways that associate with sciatic nerve injury.

Results: There was no difference in the expression of NogoA, NTR and Ntrk2. Differential genes existed in 11 differential pathways that include NogoA, NTR and Ntrk2. Pathways closely related to sciatic nerve injury are MAPK, endophagocytosis, apoptosis, neurotrophin signaling and inflammatory mediators. NTRK1, FASLG, LDLR ADRB1 and HTR2A in model rats were downregulated compared with control rats, IL1R1, CSF1R, BCL2L1 and HRH1 in model rats were upregulated compared with control rats.

Conclusion: MAPK, endophagocytic, apoptotic, neurotrophic factor and inflammatory mediators of ductal mediators may be involved in the sciatic nerve injury in rats. The differentially expressed genes in these pathways may play important roles in sciatic nerve injury.

Keywords: NTR; NogoA; Ntrk2; gene; pathway; sciatic nerve injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Nerve Regeneration
  • Neuralgia / genetics*
  • Nogo Proteins / genetics*
  • Peripheral Nerve Injuries
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Nerve Growth Factor
  • Receptor, trkB / genetics
  • Receptors, Nerve Growth Factor / genetics*
  • Schwann Cells
  • Sciatic Nerve / injuries
  • Sciatic Neuropathy
  • Signal Transduction / genetics
  • Transcriptome / genetics

Substances

  • Nogo Proteins
  • Receptor, Nerve Growth Factor
  • Receptors, Nerve Growth Factor
  • Receptor, trkB