Abstract
Two rarely phenolic acid-substituted alloses (1, 2) and one new glucoside (3), as well as nine known compounds (4-12) were isolated from rhizomes of Cibotium barometz (L.) J. Sm. Structures of 1-3 were established by extensively spectroscopic analyses (NMR, MS, etc.) and acid hydrolysis. All compounds were evaluated for the hepatoprotective activities against APAP-induced HepG2 cell damage. Compounds 1, 4-7, 10 exhibited significant hepatoprotective activities, even more strongly than positive control, bicycol. In addition, compounds 1 and 9 could reduce PC12 cell death induced by serum deprivation.
Keywords:
phenolic acid; allose; hepatoprotection.
MeSH terms
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Acetaminophen / antagonists & inhibitors
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Acetaminophen / toxicity
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Animals
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Chemical and Drug Induced Liver Injury / prevention & control
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Drugs, Chinese Herbal / chemistry
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Ferns / chemistry*
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Glucose / analogs & derivatives*
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Glucose / chemistry
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Glucose / pharmacology
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Hep G2 Cells / drug effects
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Humans
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Hydroxybenzoates / chemistry*
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Hydroxybenzoates / pharmacology
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Molecular Structure
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PC12 Cells
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Protective Agents / pharmacology
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Rats
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Rhizome / chemistry*
Substances
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Drugs, Chinese Herbal
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Glycosides
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Hydroxybenzoates
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Protective Agents
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Acetaminophen
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phenolic acid
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Glucose