Spine Intervention-An Update on Injectable Biomaterials

Nureddin Ashammakhi; Olivier Clerk-Lamalice; Gamal Baroud; Mohammad Ali Darabi; Bassem Georgy; Douglas Beall; Derrick Wagoner

doi:10.1016/j.carj.2018.11.003

Spine Intervention-An Update on Injectable Biomaterials

Can Assoc Radiol J. 2019 Feb;70(1):37-43. doi: 10.1016/j.carj.2018.11.003.

Authors

Nureddin Ashammakhi¹, Olivier Clerk-Lamalice², Gamal Baroud³, Mohammad Ali Darabi⁴, Bassem Georgy⁵, Douglas Beall², Derrick Wagoner²

Affiliations

¹ Department of Bioengineering, University of California at Los Angeles, Los Angeles, California, USA; Division of Plastic Surgery, Department of Surgery, Oulu University, Oulu, Finland; School of Technology and Innovations, University of Vaasa, Vaasa, Finland. Electronic address: n.ashammakhi@ucla.edu.
² Interventional Musculoskeletal Radiology, Clinical Radiology of Oklahoma, Edmond, Oklahoma, USA.
³ Biomechanics Laboratory, Mechanical Engineering Department, Université de Sherbrooke, Quebec, Canada.
⁴ Department of Mechanical Engineering, University of Manitoba, Winnipeg, Manitoba, Canada; Manitoba Institute for Materials, Winnipeg, Manitoba, Canada.
⁵ Department of Radiology at the University of California at San Diego and San Diego Imaging, San Diego, California, USA.

PMID: 30691561
DOI: 10.1016/j.carj.2018.11.003

Abstract

Back pain is the second most common reason for primary-care physician visits after the common cold. New understanding of the spine pathophysiology and biomechanics led to the development of novel injectable biomaterials to treat those pain generators. Although not all biomaterials are currently ready for common use, there is significant interest by the medical community to invest time, resources, and energy to optimize these injectables. This review introduces basic concepts and advancements in the field of bioinjectables tailored for the vertebral body. Also, we highlight advances in injectable biomaterials which were presented at the Groupe de Recherche Interdisciplinaire sur les Biomatériaux Ostéoarticulaires Injectables (GRIBOI) (Interdisciplinary Research Society for Injectable Osteoarticular Biomaterials) meeting in March 2018 in Los Angeles, CA. Indeed, multidisciplinary translational research and international meetings such as GRIBOI bring together scientists and clinicians with different backgrounds/expertise to discuss injectable biomaterials innovations tailored for the interventional pain management field.

Keywords: Groupe de Recherche Interdisciplinaire sur les Biomatériaux Ostéoarticulaires Injectables; Injectable; Minimally invasive; Spine; Vertebral compression fracture.

Published by Elsevier Inc.

Publication types

Review

MeSH terms

Back Pain / drug therapy*
Biocompatible Materials / administration & dosage
Biocompatible Materials / therapeutic use*
Humans
Injections, Spinal
Pain Management / methods*
Spinal Diseases / drug therapy*

Substances

Biocompatible Materials