A new triterpenoid glucoside from Leucas zeylanica

Guang-Ying Chen; Bin Zhang; Ting Zhao; Najat Nidhal; Wang Jia-Li; Xue-Ming Zhou; Dai Chun-Yan

doi:10.1080/14786419.2019.1566820

A new triterpenoid glucoside from Leucas zeylanica

Nat Prod Res. 2020 Jul;34(13):1874-1878. doi: 10.1080/14786419.2019.1566820. Epub 2019 Jan 28.

Authors

Guang-Ying Chen^{1

2}, Bin Zhang^{1

2}, Ting Zhao^{1

2}, Najat Nidhal^{1

2}, Wang Jia-Li^{1

2}, Xue-Ming Zhou^{1

2

3}, Dai Chun-Yan^{1

2}

Affiliations

¹ Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R.China.
² Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, P.R. China.
³ Key Laboratory of Ethnomedicine (Minzu University of China) Ministry of Education, Beijing, P. R. China.

PMID: 30689410
DOI: 10.1080/14786419.2019.1566820

Abstract

A new triterpenoid glucoside, leuctriterpencoside (1), along with two known compounds (2-3) were isolated from Leucas zeylanica. The structure of the new compound was elucidated using comprehensive spectroscopic methods. Compound 1 showed significant inhibitory activity against α-glucosidase (IC₅₀ value of 0.85 ± 0.12 μM).

Keywords: Leucas zeylanica; triterpenoid; α-glucosidase activity.

MeSH terms

Glucosides / chemistry
Glucosides / isolation & purification*
Glycoside Hydrolase Inhibitors / isolation & purification*
Glycoside Hydrolase Inhibitors / pharmacology
Lamiaceae / chemistry*
Lamiaceae / metabolism
Molecular Structure
Plant Extracts / chemistry
Plant Extracts / pharmacology
Triterpenes / chemistry
Triterpenes / isolation & purification*
alpha-Glucosidases / drug effects
alpha-Glucosidases / metabolism

Substances

Glucosides
Glycoside Hydrolase Inhibitors
Plant Extracts
Triterpenes
alpha-Glucosidases