Exosomes are one kind of microvesicles secreted by living cells. It contains some small non-coding RNAs (microRNA, lncRNA, circRNA, etc.) which play an important role in signal transduction. In addition, they transfer information through circulating small vesicles, regulate epithelial-mesenchymal transition, tumor microenvironment, promote microangiogenesis, regulate tumor immunity, chemoradiation resistance, and regulate cellular energy metabolism pathways, thereby promoting the occurrence, development and metastasis of hepatocellular carcinoma. This article reviews the mechanism of lncRNA in exogenous and in vivo in relation to the occurrence, development and metastasis of hepatocellular carcinoma.
外泌体是由活细胞分泌的一种微小囊泡，其内包含有一些微小非编码RNA(如microRNA、lncRNA、circRNA等)，在细胞信号传导过程中起重要作用。它们通过循环小囊泡输送信息，调节肝癌细胞的上皮间质转化、肿瘤微环境、促进微小血管生成、调节肿瘤免疫、放化疗耐药以及调节细胞能量代谢途径等，促进肝癌的发生、发展以及转移。现就外泌体内长链外编码RNA与肝癌发生、发展以及转移的机制进行简要综述。.
Keywords: Carcinoma, hepatocellular; Exosome; Long non-coding RNA.