Injectable thermosensitive hydrogel systems based on functional PEG/PCL block polymer for local drug delivery

Hongzhang Deng; Anjie Dong; Jibin Song; Xiaoyuan Chen

doi:10.1016/j.jconrel.2019.01.026

Injectable thermosensitive hydrogel systems based on functional PEG/PCL block polymer for local drug delivery

J Control Release. 2019 Mar 10:297:60-70. doi: 10.1016/j.jconrel.2019.01.026. Epub 2019 Jan 23.

Authors

Hongzhang Deng¹, Anjie Dong², Jibin Song³, Xiaoyuan Chen⁴

Affiliations

¹ MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350108, China; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, Tianjin University, Tianjin 300072, China.
² Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, Tianjin University, Tianjin 300072, China.
³ MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350108, China. Electronic address: jibinsong@fzu.edu.cn.
⁴ Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address: shawn.chen@nih.gov.

PMID: 30684513
DOI: 10.1016/j.jconrel.2019.01.026

Abstract

Injectable in situ thermosensitive hydrogels have potential applications in tissue engineering and drug delivery. The hydrogel formulations exist as aqueous solutions at room temperature but rapidly solidify into gels at 37 °C in situ, making them highly suitable for administering drugs in a minimally invasive manner to the target organ(s). The hydrogel formed with nanoparticles assembled with amphiphilic polymer blocks of polyethyleneglycol (PEG) and biodegradable polycaprolactone (PCL) have been tested as platforms for targeted and sustained drug delivery, and have shown encouraging results. In this review, we summarize the influence of the molecular weight, PEG/PCL ratio and functional structure of hydrophobic PCL blocks on the critical gelation temperature, gelling behavior and drug release kinetics of the hydrogels. The current studies on the biomedical applications of thermosensitive PEG/PCL hydrogels have also been discussed.

Keywords: Block copolymer; Hydrogel; Local drug delivery; Polycaprolactone (PCL); Thermosensitive.

Publication types

Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biocompatible Materials / administration & dosage
Biocompatible Materials / chemistry*
Drug Compounding
Drug Liberation
Humans
Hydrogels / administration & dosage
Hydrogels / chemistry*
Hydrophobic and Hydrophilic Interactions
Kinetics
Molecular Structure
Molecular Weight
Nanocapsules / administration & dosage
Nanocapsules / chemistry*
Phase Transition
Polyesters / chemistry*
Polyethylene Glycols / chemistry*
Structure-Activity Relationship
Temperature

Substances

Biocompatible Materials
Hydrogels
Nanocapsules
Polyesters
polycaprolactone
Polyethylene Glycols