Micromanaging human placental function: differential microRNA expression in feto-placental endothelial cells of gestational diabetes pregnancies

Boris Novakovic; Toby Mansell; Richard Saffery

doi:10.1042/CS20180901

Micromanaging human placental function: differential microRNA expression in feto-placental endothelial cells of gestational diabetes pregnancies

Clin Sci (Lond). 2019 Jan 25;133(2):315-319. doi: 10.1042/CS20180901. Print 2019 Jan 31.

Authors

Boris Novakovic¹, Toby Mansell¹, Richard Saffery²

Affiliations

¹ Epigenetics Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC, 3052, Australia and Department of Paediatrics, University of Melbourne, Parkville, VIC, 3052, Australia.
² Epigenetics Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC, 3052, Australia and Department of Paediatrics, University of Melbourne, Parkville, VIC, 3052, Australia Richard.saffery@mcri.edu.au.

PMID: 30683714
DOI: 10.1042/CS20180901

Abstract

Healthy development in utero relies on the appropriate exchange of nutrients and other signalling between the maternal and fetal circulations. Disruption to this fine balance is associated with several pregnancy and adverse birth outcomes, including gestational diabetes mellitus (GDM). This is a complex condition influenced by genetic, environment and potentially epigenetic factors in association with a range of altered developmental outcomes. A recent study, published in Clinical Science, explores miRNAs as a molecular mechanism underpinning the altered function of placental endothelial cells in GDM pregnancies.

Keywords: endothelial cell; gestational diabetes; miRNA; placenta.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Diabetes, Gestational*
Endothelial Cells
Female
Humans
MicroRNAs*
Placenta
Pregnancy

Substances

MicroRNAs