Towards Closed-Loop Integration of Point-of-Care Technologies

Edward K W Tan; Yan Zi Au; Gita Khalili Moghaddam; Luigi G Occhipinti; Christopher R Lowe

doi:10.1016/j.tibtech.2018.12.004

Towards Closed-Loop Integration of Point-of-Care Technologies

Trends Biotechnol. 2019 Jul;37(7):775-788. doi: 10.1016/j.tibtech.2018.12.004. Epub 2019 Jan 22.

Authors

Edward K W Tan¹, Yan Zi Au², Gita Khalili Moghaddam³, Luigi G Occhipinti⁴, Christopher R Lowe⁵

Affiliations

¹ Department of Engineering, University of Cambridge, Cambridge CB3 0FA, UK.
² Wellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
³ Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
⁴ Cambridge Graphene Centre, University of Cambridge, Cambridge CB3 0FA, UK.
⁵ Cambridge Academy of Therapeutic Sciences, Department of Pharmacology, Cambridge CB2 1PD, UK. Electronic address: crl1@cam.ac.uk.

PMID: 30683459
DOI: 10.1016/j.tibtech.2018.12.004

Abstract

Point-of-care (PoC) diagnostics promises to yield test results accessible anytime and anywhere. Its application has expanded from providing healthcare necessities to the real-time monitoring of the ageing and health conscious population. Following the evolving consumer demand, there is a trend toward developing non- and minimally invasive PoC tests. Emerging PoC sensors have not only demonstrated multifunctional capabilities such as sweat stimulation but also can be connected to drug delivery units via a wireless network, enabling an active role of the technology in disease management. This review article summarises the latest developments in non- and minimally invasive PoC diagnostics and provides an overview on the progress towards closed-loop integration of complementary technologies for comprehensive and autonomous patient care.

Keywords: autonomous; closed loop; diagnostics; minimally invasive; non-invasive; point of care.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biosensing Techniques / methods
Biosensing Techniques / trends
Body Fluids / chemistry*
Diagnostic Tests, Routine / methods*
Diagnostic Tests, Routine / trends*
Disease Management*
Humans
Point-of-Care Systems / trends*