An Enantioselective Potentiometric Sensor for 2-Amino-1-Butanol Based on Chiral Porous Organic Cage CC3-R

Molecules. 2019 Jan 24;24(3):420. doi: 10.3390/molecules24030420.

Abstract

Porous organic cages (POCs) have attracted extensive attention due to their unique structures and tremendous application potential in numerous areas. In this study, an enantioselective potentiometric sensor composed of a polyvinyl chloride (PVC) membrane electrode modified with CC3-R POC material was used for the recognition of enantiomers of 2-amino-1-butanol. After optimisation, the developed sensor exhibited enantioselectivity toward S-2-amino-1-butanol ( log K S , R P o t = -0.98) with acceptable sensitivity, and a near-Nernstian response of 25.8 ± 0.3 mV/decade within a pH range of 6.0⁻9.0.

Keywords: 2-amino-1-butanol; CC3-R; PVC membrane electrode; chiral porous organic cage; enantioselective potentiometric sensor.

MeSH terms

  • Amino Alcohols / chemistry*
  • Electrochemical Techniques
  • Electrodes
  • Hydrogen-Ion Concentration
  • Membranes, Artificial
  • Molecular Structure
  • Polyvinyl Chloride / chemistry
  • Porosity
  • Potentiometry
  • Sensitivity and Specificity
  • Stereoisomerism

Substances

  • Amino Alcohols
  • Membranes, Artificial
  • Polyvinyl Chloride
  • 2-amino-1-butanol