Engineering graphene oxide with ultrasmall SPIONs and smart drug release for cancer theranostics

Yu Luo; Yan Tang; Tianzhi Liu; Qian Chen; Xiaohan Zhou; Ning Wang; Ming Ma; Yingsheng Cheng; Hangrong Chen

doi:10.1039/c8cc09185d

Engineering graphene oxide with ultrasmall SPIONs and smart drug release for cancer theranostics

Chem Commun (Camb). 2019 Feb 7;55(13):1963-1966. doi: 10.1039/c8cc09185d.

Authors

Yu Luo¹, Yan Tang, Tianzhi Liu, Qian Chen, Xiaohan Zhou, Ning Wang, Ming Ma, Yingsheng Cheng, Hangrong Chen

Affiliation

¹ Country State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050, P. R. China. hrchen@mail.sic.ac.cn.

PMID: 30681672
DOI: 10.1039/c8cc09185d

Abstract

A smart nanotheranostics nanoplatform was constructed using engineered graphene oxide and the in situ growth of ultrasmall superparamagnetic iron oxide particles (SPIONs). The construction of such a novel theranostics nanoplatform shows great potential in tumor theranostics, especially for T1-weighted magnetic resonance (T1-MR) imaging guided, pH-sensitive chemotherapy.

MeSH terms

Antineoplastic Agents / therapeutic use*
Doxorubicin / therapeutic use*
Drug Delivery Systems*
Drug Liberation
Ferric Compounds / chemistry*
Graphite / chemistry*
Humans
Hydrogen-Ion Concentration
Magnetic Resonance Imaging
Magnetite Nanoparticles / chemistry*
Neoplasms / drug therapy*
Particle Size
Surface Properties
Theranostic Nanomedicine*

Substances

Antineoplastic Agents
Ferric Compounds
Magnetite Nanoparticles
graphene oxide
ferric oxide
Graphite
Doxorubicin