Facile synthesis of carbon fiber reinforced polymer-hydroxyapatite ternary composite: A mechanically strong bioactive bone graft

Mater Sci Eng C Mater Biol Appl. 2019 Apr:97:388-396. doi: 10.1016/j.msec.2018.12.064. Epub 2018 Dec 20.

Abstract

Carbon fiber reinforced carboxymethyl cellulose-hydroxyapatite ternary composites have been synthesized by a simple wet precipitation method for weight bearing orthopedic application. Composites were synthesized with the incorporation of chemically functionalized carbon fibers. The functional groups onto the surface of fibers induced the formation of hydroxyapatite at the bridging position through which fibers were effectively bound with matrix. Consequently, the flexural strength and compressive strength of composite have reached to 140 MPa and 118 MPa, respectively. The flexural modulus of the composite is in the range of 9-22 GPa. In-vitro cell study showed that the composite possesses excellent cell proliferation and differentiation ability. With these excellent mechanical and biological properties, synthesized composite exhibits potential to be used as a mechanically compatible bioactive bone graft.

Keywords: Bone graft; Carbon fiber; Carboxymethyl cellulose; Composite; Hydroxyapatite.

MeSH terms

  • Alkaline Phosphatase / metabolism
  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry*
  • Calcification, Physiologic
  • Carbon Fiber / chemistry*
  • Carboxymethylcellulose Sodium / chemistry
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Compressive Strength
  • Durapatite / chemistry*
  • Materials Testing
  • Mice
  • Microscopy, Electron, Scanning
  • Osteoblasts / cytology*
  • Osteoblasts / physiology
  • Prostheses and Implants
  • Spectroscopy, Fourier Transform Infrared
  • Weight-Bearing
  • X-Ray Diffraction

Substances

  • Biocompatible Materials
  • Carbon Fiber
  • Durapatite
  • Alkaline Phosphatase
  • Carboxymethylcellulose Sodium