Multifunctional nanoplatform for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis

Xianxian Yao; Peng Yang; Zhaokui Jin; Qin Jiang; Ranran Guo; Ruihong Xie; Qianjun He; Wuli Yang

doi:10.1016/j.biomaterials.2019.01.026

Multifunctional nanoplatform for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis

Biomaterials. 2019 Mar:197:268-283. doi: 10.1016/j.biomaterials.2019.01.026. Epub 2019 Jan 18.

Authors

Xianxian Yao¹, Peng Yang¹, Zhaokui Jin², Qin Jiang¹, Ranran Guo¹, Ruihong Xie¹, Qianjun He³, Wuli Yang⁴

Affiliations

¹ State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
² Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, Guangdong, China.
³ Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, Guangdong, China. Electronic address: nanoflower@126.com.
⁴ State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China. Electronic address: wlyang@fudan.edu.cn.

PMID: 30677556
DOI: 10.1016/j.biomaterials.2019.01.026

Abstract

A multifunctional CO/thermo/chemotherapy nanoplatform is here reported, which is composed of mesoporous carbon nanoparticles (MCN) as near infrared (NIR)-responsive drug carrier, doxorubicin (DOX) as chemotherapeutic drug and triiron dodecacarbonyl (FeCO) as thermosensitive CO prodrug. The nanoplatform could absorb near-infrared (NIR) light and convert it into ample heat to trigger CO release and could also release DOX in the acidic tumor microenvironment. More importantly, the generated CO molecules successfully increase cancer cell sensitivity to chemotherapeutics by the ferroptosis pathway. Subsequently, under the guidance of photoacoustic imaging, the FeCO-DOX@MCN nanoplatform demonstrates high treatment efficacies in vitro and in vivo by combination of chemotherapy, photothermal therapy and gas therapy. This multifunctional platform with excellent antitumor efficacy has great potential in precision cancer therapy.

Keywords: Carbon monoxide; Controlled release; Ferroptosis; Mesoporous materials; Photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibiotics, Antineoplastic / administration & dosage*
Antibiotics, Antineoplastic / pharmacology
Antibiotics, Antineoplastic / therapeutic use
Carbon Monoxide / administration & dosage*
Carbon Monoxide / pharmacology
Carbon Monoxide / therapeutic use
Cell Line, Tumor
Delayed-Action Preparations / chemistry
Doxorubicin / administration & dosage*
Doxorubicin / pharmacology
Doxorubicin / therapeutic use
Female
Ferroptosis / drug effects*
Humans
Hyperthermia, Induced
Iron Compounds / administration & dosage*
Iron Compounds / pharmacology
Iron Compounds / therapeutic use
Mice, Inbred BALB C
Mice, Nude
Nanoparticles / chemistry
Neoplasms / diagnostic imaging
Neoplasms / pathology
Neoplasms / therapy*
Photoacoustic Techniques
Porosity

Substances

Antibiotics, Antineoplastic
Delayed-Action Preparations
Iron Compounds
dodecacarbonyl iron
Carbon Monoxide
Doxorubicin