Inhibition of antigen presentation by Brucella: many more than many ways

Microbes Infect. 2019 Apr-May;21(3-4):136-142. doi: 10.1016/j.micinf.2018.12.004. Epub 2019 Jan 21.

Abstract

Brucella infection activates the immune system and favors the differentiation of CD4+ and CD8+ T cells. To persist during a long time inside macrophages evading immune surveillance of these T cells the pathogen must exploit different evasion strategies. We review the mechanisms whereby Brucella, through TLR signaling, inhibits MHC class I and II antigen presentation, allowing infected macrophages to become effective niches for Brucella survival.

Keywords: Antigen presentation; Brucella; Macrophages; TLR.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Brucella / immunology*
  • Brucellosis / immunology*
  • Brucellosis / microbiology
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Immune Evasion*
  • Macrophages / immunology
  • Macrophages / microbiology
  • Signal Transduction
  • Toll-Like Receptors / metabolism

Substances

  • Histocompatibility Antigens Class II
  • Toll-Like Receptors