Brucella infection activates the immune system and favors the differentiation of CD4+ and CD8+ T cells. To persist during a long time inside macrophages evading immune surveillance of these T cells the pathogen must exploit different evasion strategies. We review the mechanisms whereby Brucella, through TLR signaling, inhibits MHC class I and II antigen presentation, allowing infected macrophages to become effective niches for Brucella survival.
Keywords: Antigen presentation; Brucella; Macrophages; TLR.
Copyright © 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.