Abstract
This study aimed to examine the antidiabetic effects of various concentrations of adlay bran oil (ABO) in high fat diet and streptozotocin-induced diabetic rats. Dietary supplementation with 10% ABO for 4 weeks effectively decreased the blood triacylglycerol, glucose, and total cholesterol levels in diabetic rats, although body weight remained the same. The mRNA and protein expressions of hepatic glucose transporter 2 (GLUT-2) and phosphoenolpyruvate carboxykinase (PEPCK) were increased and that of glucokinase (GCK) were decreased in diabetic rats. However, 10% ABO treatment reduced the mRNA and protein expressions of GLUT-2 and PEPCK and elevated the expression of hepatic GCK in diabetic rats. Thus, ABO enhanced hepatic glucose metabolism to decrease blood glucose in diabetic rats. In addition, 10% ABO supplementation increased the expression of phosphorylated protein kinase B (Akt) relative to the total Akt levels in the muscles of diabetic rats, indicating enhanced insulin sensitivity. The results indicate that ABO displays a potential for improving hyperlipidemia and hyperglycemia in diabetes by enhancing insulin sensitivity and hepatic glucose metabolism.
MeSH terms
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Animals
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Blood Glucose / metabolism
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Coix / chemistry*
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Diabetes Mellitus, Experimental / complications
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Diabetes Mellitus, Experimental / drug therapy
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Diabetes Mellitus, Experimental / metabolism
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Diabetes Mellitus, Type 2 / complications*
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / metabolism
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Diet, High-Fat
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Glucokinase / metabolism
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Gluconeogenesis / drug effects*
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Glucose Transporter Type 2 / metabolism
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Hyperglycemia / blood
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Hyperglycemia / prevention & control*
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Hyperlipidemias / blood
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Hyperlipidemias / prevention & control*
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Hypoglycemic Agents / pharmacology
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Hypoglycemic Agents / therapeutic use
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Hypolipidemic Agents / pharmacology
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Hypolipidemic Agents / therapeutic use
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Insulin Resistance
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Lipids / blood
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Liver / drug effects*
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Liver / metabolism
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Male
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Muscles / metabolism
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Phosphoenolpyruvate Carboxykinase (ATP) / metabolism
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Phytotherapy
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Plant Oils / pharmacology
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Plant Oils / therapeutic use*
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Proto-Oncogene Proteins c-akt / metabolism
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RNA, Messenger / metabolism
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Rats, Sprague-Dawley
Substances
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Blood Glucose
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Glucose Transporter Type 2
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Hypoglycemic Agents
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Hypolipidemic Agents
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Lipids
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Plant Oils
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RNA, Messenger
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Slc2a2 protein, rat
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Glucokinase
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Proto-Oncogene Proteins c-akt
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Phosphoenolpyruvate Carboxykinase (ATP)