Emergence of enterovirus D68 clade D1, France, August to November 2018

Euro Surveill. 2019 Jan;24(3):1800699. doi: 10.2807/1560-7917.ES.2019.24.3.1800699.

Abstract

We report a seasonal increase of enterovirus D68 (EV-D68) cases in France, with 54 cases detected between 19 August and 14 November 2018. Molecular typing revealed that 20 of 32 of the isolates belonged to clade D1, only sporadically detected before in France. Median age of D1-cases was 42 years, 10 developed severe respiratory signs and one had neurological complications. The 2018-D1 viruses showed a genetic divergence of 3.34 % with D1 viruses identified previously.

Keywords: emergence; enterovirus D68; metagenomics; outbreak; respiratory infection; whole genome sequencing.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Communicable Diseases, Emerging / epidemiology
  • Disease Outbreaks
  • Enterovirus D, Human / genetics
  • Enterovirus D, Human / isolation & purification*
  • Enterovirus Infections / diagnosis*
  • Enterovirus Infections / epidemiology*
  • Enterovirus Infections / virology
  • Female
  • France / epidemiology
  • Genotype
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Molecular Typing
  • Phylogeny
  • Population Surveillance / methods
  • Respiratory Tract Infections / epidemiology*
  • Sequence Analysis, DNA
  • Young Adult