Developmental Biology: Hox Timing Determines Limb Placement

John J Young; Phil Grayson; Clifford J Tabin

doi:10.1016/j.cub.2018.11.068

Developmental Biology: Hox Timing Determines Limb Placement

Curr Biol. 2019 Jan 21;29(2):R52-R54. doi: 10.1016/j.cub.2018.11.068.

Authors

John J Young¹, Phil Grayson², Clifford J Tabin³

Affiliations

¹ Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
² Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
³ Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: tabin@genetics.med.harvard.edu.

PMID: 30668947
DOI: 10.1016/j.cub.2018.11.068

Abstract

Hox genes are known to determine vertebral identity along with being required for normal limb patterning. A new study now finds that differential expression timing of Hox genes in the lateral plate mesoderm determines limb placement as well.

Publication types

Comment

MeSH terms

Animals
Body Patterning
Developmental Biology
Forelimb
Gastrulation*
Gene Expression Regulation, Developmental
Genes, Homeobox*
Mesoderm

Grants and funding

R01 HD032443/HD/NICHD NIH HHS/United States