P-Mart: Interactive Analysis of Ion Abundance Global Proteomics Data

J Proteome Res. 2019 Mar 1;18(3):1426-1432. doi: 10.1021/acs.jproteome.8b00840. Epub 2019 Feb 6.

Abstract

The use of mass-spectrometry-based techniques for global protein profiling of biomedical or environmental experiments has become a major focus in research centered on biomarker discovery; however, one of the most important issues recently highlighted in the new era of omics data generation is the ability to perform analyses in a robust and reproducible manner. This has been hypothesized to be one of the issues hindering the ability of clinical proteomics to successfully identify clinical diagnostic and prognostic biomarkers of disease. P-Mart ( https://pmart.labworks.org ) is a new interactive web-based software environment that enables domain scientists to perform quality-control processing, statistics, and exploration of large-complex proteomics data sets without requiring statistical programming. P-Mart is developed in a manner that allows researchers to perform analyses via a series of modules, explore the results using interactive visualization, and finalize the analyses with a collection of output files documenting all stages of the analysis and a report to allow reproduction of the analysis.

Keywords: exploratory data analysis; proteomics; reproducibility; software; statistics; visualization; web service.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biomarkers*
  • Humans
  • Internet
  • Ions / chemistry
  • Mass Spectrometry / methods
  • Mass Spectrometry / statistics & numerical data*
  • Prognosis
  • Proteomics / methods
  • Proteomics / statistics & numerical data*
  • Software*

Substances

  • Biomarkers
  • Ions