Vibration analysis of healthy skin: toward a noninvasive skin diagnosis methodology

J Biomed Opt. 2019 Jan;24(1):1-11. doi: 10.1117/1.JBO.24.1.015001.

Abstract

Several noninvasive imaging techniques have been developed to monitor the health of skin and enhance the diagnosis of skin diseases. Among them, skin elastography is a popular technique used to measure the elasticity of the skin. A change in the elasticity of the skin can influence its natural frequencies and mode shapes. We propose a technique to use the resonant frequencies and mode shapes of the skin to monitor its health. Our study demonstrates how the resonant frequencies and mode shapes of skin can be obtained using numerical and experimental analysis. In our study, natural frequencies and mode shapes are obtained via two methods: (1) finite element analysis: an eigensolution is performed on a finite element model of normal skin, including stratum corneum, epidermis, dermis, and subcutaneous layers and (2) digital image correlation (DIC): several in-vivo measurements have been performed using DIC. The experimental results show a correlation between the DIC and FE results suggesting a noninvasive method to obtain vibration properties of the skin. This method can be further examined to be eventually used as a method to differentiate healthy skin from diseased skin. Prevention, early diagnosis, and treatment are critical in helping to reduce the incidence, morbidity, and mortality associated with skin cancer; thus, making the current study significant and important in the field of skin biomechanics.

Keywords: basal cell carcinoma; digital image correlation; eigensolution; finite element analysis; healthy skin; image processing; malignant melanoma; noninvasive diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Biomechanical Phenomena
  • Computer Simulation
  • Diagnosis, Computer-Assisted
  • Elasticity
  • Elasticity Imaging Techniques / methods*
  • Finite Element Analysis
  • Healthy Volunteers
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Melanoma / diagnostic imaging
  • Models, Biological
  • Skin / diagnostic imaging*
  • Skin Diseases / diagnostic imaging*
  • Vibration
  • Young Adult