Diffuse Atypical Cystic Brain Metastases in ALK+ NSCLC Treated With Whole Brain Radiation and Second-Generation ALK-Targeted Therapy

Pract Radiat Oncol. 2019 Mar;9(2):e129-e133. doi: 10.1016/j.prro.2018.11.002. Epub 2019 Jan 18.

Authors

William R Grubb¹, Mitchell Machtay², Afshin Dowlati², Tithi Biswas²

Affiliations

¹ University Hospitals Cleveland Medical Center, Cleveland, Ohio. Electronic address: William.grubb@uhhospitals.org.
² University Hospitals Cleveland Medical Center, Cleveland, Ohio.

PMID: 30665865
DOI: 10.1016/j.prro.2018.11.002

No abstract available

Publication types

Case Reports

MeSH terms

Brain / diagnostic imaging
Brain Neoplasms / diagnostic imaging
Brain Neoplasms / genetics
Brain Neoplasms / secondary
Brain Neoplasms / therapy*
Carbazoles / therapeutic use
Carcinoma, Non-Small-Cell Lung / diagnostic imaging
Carcinoma, Non-Small-Cell Lung / secondary
Carcinoma, Non-Small-Cell Lung / therapy*
Chemoradiotherapy / methods*
Humans
Lung Neoplasms / genetics
Lung Neoplasms / pathology*
Magnetic Resonance Imaging
Male
Middle Aged
Oncogene Proteins, Fusion / antagonists & inhibitors
Oncogene Proteins, Fusion / genetics
Piperidines / therapeutic use
Protein Kinase Inhibitors / therapeutic use*
Treatment Outcome

Substances

Carbazoles
EML4-ALK fusion protein, human
Oncogene Proteins, Fusion
Piperidines
Protein Kinase Inhibitors
alectinib