Abstract
Quercetin impact on lipid bilayers suggests a dual action mechanism at cell membranes. This widespread polyphenol displays high partition with low interference in the more fluid membrane domains, more vulnerable to oxidative attack, but strong perturbation of cholesterol/sphingolipid enriched domains, where signalling platforms are expected to assemble.
MeSH terms
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Binding Sites
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Cholesterol / chemistry
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Cholesterol / metabolism
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Fluorescence Polarization
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Lipid Bilayers / chemistry*
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Lipid Bilayers / metabolism
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Molecular Dynamics Simulation
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Quercetin / chemistry*
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Quercetin / metabolism
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Sphingolipids / chemistry
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Sphingolipids / metabolism
Substances
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Lipid Bilayers
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Sphingolipids
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Cholesterol
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Quercetin