Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue

Adam C Lehnig; Revati S Dewal; Lisa A Baer; Kathryn M Kitching; Vitor Rosetto Munoz; Peter J Arts; Devin A Sindeldecker; Francis J May; Hans P M M Lauritzen; Laurie J Goodyear; Kristin I Stanford

doi:10.1016/j.isci.2018.12.033

Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue

iScience. 2019 Jan 25:11:425-439. doi: 10.1016/j.isci.2018.12.033. Epub 2019 Jan 3.

Affiliations

¹ Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12(th) Avenue, Columbus, OH 43210, USA.
² Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12(th) Avenue, Columbus, OH 43210, USA; Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
³ Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA 02215, USA.
⁴ Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
⁵ Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 460 W. 12(th) Avenue, Columbus, OH 43210, USA. Electronic address: kristin.stanford@osumc.edu.

Abstract

Exercise affects whole-body metabolism through adaptations to various tissues, including adipose tissue (AT). Recent studies investigated exercise-induced adaptations to AT, focusing on inguinal white adipose tissue (WAT), perigonadal WAT, and interscapular brown adipose tissue (iBAT). Although these AT depots play important roles in metabolism, they account for only ∼50% of the AT mass in a mouse. Here, we investigated the effects of 3 weeks of exercise training on all 14 AT depots. Exercise induced depot-specific effects in genes involved in mitochondrial activity, glucose metabolism, and fatty acid uptake and oxidation in each adipose tissue (AT) depot. These data demonstrate that exercise training results in unique responses in each AT depot; identifying the depot-specific adaptations to AT in response to exercise is essential to determine how AT contributes to the overall beneficial effect of exercise.

Keywords: Cell Biology; Molecular Biology; Molecular Mechanism of Behavior; Specialized Functions of Cells.

Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue

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Abstract

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