Biocompatible Fe3O4/chitosan scaffolds with high magnetism

Jianhua Ge; Mengdi Zhai; Yi Zhang; Jie Bian; Junling Wu

doi:10.1016/j.ijbiomac.2019.01.077

Biocompatible Fe₃O₄/chitosan scaffolds with high magnetism

Int J Biol Macromol. 2019 May 1:128:406-413. doi: 10.1016/j.ijbiomac.2019.01.077. Epub 2019 Jan 17.

Authors

Jianhua Ge¹, Mengdi Zhai², Yi Zhang³, Jie Bian², Junling Wu⁴

Affiliations

¹ Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, China; School of Materials Science & Engineering, Shandong University, Jinan 250100, China. Electronic address: gejianhua@sdu.edu.cn.
² Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, China; School of Materials Science & Engineering, Shandong University, Jinan 250100, China.
³ School of Environmental Science and Engineering, Shandong University, Jinan 250100, China. Electronic address: zhangyi0622@gmail.com.
⁴ School of Stomatology, Shandong University, Jinan 250100, China; Shandong Provincial Key Laboratory of Oral Biomedicine, Shandong University, Jinan 250100, China.

PMID: 30660562
DOI: 10.1016/j.ijbiomac.2019.01.077

Abstract

Durable and biocompatible magnetic scaffolds prepared by simple approaches are important for the development of tissue engineering. In this work, by freeze-drying method and without using any crosslinker, we successfully fabricated Fe₃O₄/chitosan magnetic scaffolds that belong to hard magnetic materials and are stable in physiological fluid. In vitro biocompatibility assay showed that mouse mesenchymal progenitor cells grow normally on the surface of the scaffolds. So these magnetic scaffolds have potentials to be used in tissue engineering as implants that independently direct drug targeting.

Keywords: Biocompatibility; Chitosan; Magnetic scaffolds.

MeSH terms

Animals
Biocompatible Materials / chemistry*
Biocompatible Materials / toxicity
Cell Line
Chitosan / chemistry*
Ferrosoferric Oxide / chemistry*
Ferrosoferric Oxide / toxicity
Freeze Drying
Magnetic Phenomena*
Mice
Porosity
Surface Properties

Substances

Biocompatible Materials
Chitosan
Ferrosoferric Oxide