Aquilariaenes A-H, eight new diterpenoids from Chinese eaglewood

Abstract

Aquilariaenes A-H (1-8), eight new diterpenoids and nor-diterpenoids (1-8) belonging to abietane or pimarane, were isolated from the petroleum ether extract of Chinese eaglewood. Their structures were elucidated on the basis of extensive spectroscopic methods including HRESIMS, IR, 1D and 2D NMR spectroscopic data analyses. Antidepressant activities of isolates for in vitro inhibition of serotonin and norepinephrine reuptake in rat brain synaptosomes were evaluated.

Keywords: Abietane; Aquilaria sinensis; Aquilariaenes; Chinese eaglewood; Diterpenoids; Pimarane.