Abstract
Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.
Keywords:
Middle East respiratory syndrome coronavirus; animal models; coronavirus spike glycoprotein; correlates of immunity; severe acute respiratory syndrome coronavirus; vaccine platforms.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Neutralizing / immunology
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Antibodies, Viral / immunology
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Coronavirus Infections / immunology
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Coronavirus Infections / prevention & control*
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Disease Models, Animal
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Humans
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Mice
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Middle East Respiratory Syndrome Coronavirus / genetics
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Middle East Respiratory Syndrome Coronavirus / immunology*
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Spike Glycoprotein, Coronavirus / genetics
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Spike Glycoprotein, Coronavirus / immunology
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Vaccination
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Vaccines, Attenuated / immunology
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Viral Vaccines / immunology*
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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Spike Glycoprotein, Coronavirus
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Vaccines, Attenuated
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Viral Vaccines