PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma

Haematologica. 2019 Jul;104(7):e310-e313. doi: 10.3324/haematol.2018.194688. Epub 2019 Jan 17.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminopyridines / pharmacology*
  • Benzamides / pharmacology*
  • Drug Resistance, Neoplasm / drug effects*
  • Focal Adhesion Kinase 1 / antagonists & inhibitors*
  • Focal Adhesion Kinase 2 / antagonists & inhibitors*
  • Humans
  • Hypoxia / physiopathology*
  • Multiple Myeloma / drug therapy*
  • Multiple Myeloma / metabolism
  • Multiple Myeloma / pathology
  • Proteasome Inhibitors / pharmacology
  • Pyrazines / pharmacology*
  • Sulfonamides / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Aminopyridines
  • Benzamides
  • PND 1186
  • Proteasome Inhibitors
  • Pyrazines
  • Sulfonamides
  • defactinib
  • Focal Adhesion Kinase 1
  • Focal Adhesion Kinase 2
  • PTK2 protein, human
  • PTK2B protein, human