PEGylated mesoporous Bi2S3 nanostars loaded with chlorin e6 and doxorubicin for fluorescence/CT imaging-guided multimodal therapy of cancer

Lihong Sun; Mengmeng Hou; Lei Zhang; Dongxiang Qian; Qingquan Yang; Zhigang Xu; Yuejun Kang; Peng Xue

doi:10.1016/j.nano.2018.12.013

PEGylated mesoporous Bi₂S₃ nanostars loaded with chlorin e6 and doxorubicin for fluorescence/CT imaging-guided multimodal therapy of cancer

Nanomedicine. 2019 Apr:17:1-12. doi: 10.1016/j.nano.2018.12.013. Epub 2019 Jan 14.

Authors

Lihong Sun¹, Mengmeng Hou¹, Lei Zhang², Dongxiang Qian³, Qingquan Yang⁴, Zhigang Xu¹, Yuejun Kang⁵, Peng Xue⁶

Affiliations

¹ Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Faculty of Materials and Energy, Southwest University, Chongqing, China; Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Chongqing, China.
² Institute of Sericulture and System Biology, Southwest University, Chongqing, China.
³ The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁴ The Second Affiliated Hospital of Shenyang Medical College, Shenyang, China.
⁵ Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Faculty of Materials and Energy, Southwest University, Chongqing, China; Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Chongqing, China. Electronic address: yjkang@swu.edu.cn.
⁶ Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Faculty of Materials and Energy, Southwest University, Chongqing, China; Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Chongqing, China. Electronic address: xuepeng@swu.edu.cn.

PMID: 30654184
DOI: 10.1016/j.nano.2018.12.013

Abstract

Taking advantage of the mesoporous structure of bismuth sulfide nanostars (Bi₂S₃ NSs), a chemotherapeutic drug of doxorubicin (DOX) and a photosensitizer of chlorin e6 (Ce6) were concurrently loaded in the PEGylated Bi₂S₃ NSs to formulate a multifunctional nanocomplex (BPDC NSs) for tumor theranostics. BPDC NSs have excellent photothermal conversion efficiency and a capacity of yielding reactive oxygen species (ROS) upon laser irradiation, and can realize on-demand drug release by either pH-activation or thermal induction. Accumulation of the nanodrug could be monitored in real-time by infrared thermal imaging, fluorescence imaging and computed tomography (CT). More importantly, the combination effects of photothermal therapy (PTT), photodynamic therapy (PDT) and chemotherapy were demonstrated to dramatically suppress solid tumors without recurrence in vivo. Featuring low systemic toxicity and high biocompatibility, this nanoplatform could be a promising derivative of Bi₂S₃ NSs for imaging-guided theranostics of cancer.

Keywords: Bismuth (bi) chalcogenides; Cancer theranostics; Chlorin e6; Controlled drug release; Doxorubicin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibiotics, Antineoplastic / administration & dosage*
Antibiotics, Antineoplastic / therapeutic use
Bismuth / therapeutic use
Cell Line, Tumor
Chlorophyllides
Delayed-Action Preparations / therapeutic use
Doxorubicin / administration & dosage*
Doxorubicin / therapeutic use
Hyperthermia, Induced
Mice
Nanoparticles / therapeutic use
Nanoparticles / ultrastructure
Neoplasms / diagnostic imaging*
Neoplasms / therapy*
Optical Imaging
Photochemotherapy
Photosensitizing Agents / administration & dosage*
Photosensitizing Agents / therapeutic use
Polyethylene Glycols / therapeutic use
Porosity
Porphyrins / administration & dosage*
Porphyrins / therapeutic use
Sulfides / therapeutic use
Theranostic Nanomedicine
Tomography, X-Ray Computed

Substances

Antibiotics, Antineoplastic
Chlorophyllides
Delayed-Action Preparations
Photosensitizing Agents
Porphyrins
Sulfides
Polyethylene Glycols
phytochlorin
Doxorubicin
Bismuth
bismuth sulfide