Costatamins A - C, new 4-phenylcoumarins with anti-inflammatory activity from the Australian woodland tree Angophora costata (Myrtaceae)

Ritesh Raju; Ahilya Singh; Frances Bodkin; Gerald Münch

doi:10.1016/j.fitote.2019.01.004

Costatamins A - C, new 4-phenylcoumarins with anti-inflammatory activity from the Australian woodland tree Angophora costata (Myrtaceae)

Fitoterapia. 2019 Mar:133:171-174. doi: 10.1016/j.fitote.2019.01.004. Epub 2019 Jan 14.

Authors

Ritesh Raju¹, Ahilya Singh², Frances Bodkin², Gerald Münch²

Affiliations

¹ Department of Pharmacology, Western Sydney University, Campbelltown Campus, Sydney, Australia. Electronic address: r.raju@westernsydney.edu.au.
² Department of Pharmacology, Western Sydney University, Campbelltown Campus, Sydney, Australia.

PMID: 30654131
DOI: 10.1016/j.fitote.2019.01.004

Abstract

The bioassay-guided isolation of new anti-inflammatory metabolites from the Australian Indigenous plant Angophora costata led to the discovery of three new 4-phenylcoumarins, costatamins A - C (1-3). The structures were determined by detailed spectroscopic analysis. Costatamins A - C were evaluated for their inhibitory effects on (a) NO production and (b) TNF-α release in RAW 264.7 macrophages, displaying an IC(50) value of 20-30 μg/mL for both the inflammatory markers.

Keywords: 4-Phenylcoumarin; Angophora costata; Anti-inflammatory; Tumor Necrosis Factor-α.

MeSH terms

Animals
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Australia
Coumarins / isolation & purification
Coumarins / pharmacology*
Macrophages / drug effects
Mice
Molecular Structure
Myrtaceae / chemistry*
Nitric Oxide / metabolism
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
RAW 264.7 Cells
Trees / chemistry
Tumor Necrosis Factor-alpha / metabolism

Substances

Anti-Inflammatory Agents
Coumarins
Phytochemicals
Tumor Necrosis Factor-alpha
4-phenylcoumarin
Nitric Oxide