A TREK to Translate Genetics to Mechanisms of Migraine

Rose Z Hill; Diana M Bautista

doi:10.1016/j.neuron.2018.12.034

A TREK to Translate Genetics to Mechanisms of Migraine

Neuron. 2019 Jan 16;101(2):193-195. doi: 10.1016/j.neuron.2018.12.034.

Authors

Rose Z Hill¹, Diana M Bautista²

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dbautista@berkeley.edu.

PMID: 30653930
DOI: 10.1016/j.neuron.2018.12.034

Abstract

In this issue of Neuron, Royal et al. (2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal hyperexcitability and migraine in rodents.

Publication types

Comment

MeSH terms

Humans
Migraine Disorders*
Mutation
Neurons
Potassium Channels / genetics*

Substances

Potassium Channels