N-Heterocyclic Carbene Catalyzed Synthesis of Dihydroxybenzophenones from β-Methylenals and Aurones

Kun-Quan Chen; Zhi Luo; Zhong-Hua Gao; Song Ye

doi:10.1002/chem.201806225

N-Heterocyclic Carbene Catalyzed Synthesis of Dihydroxybenzophenones from β-Methylenals and Aurones

Chemistry. 2019 Mar 1;25(13):3253-3256. doi: 10.1002/chem.201806225. Epub 2019 Feb 6.

Authors

Kun-Quan Chen^{1

2}, Zhi Luo^{1

2}, Zhong-Hua Gao^{1

2}, Song Ye^{1

2}

Affiliations

¹ Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.

PMID: 30653756
DOI: 10.1002/chem.201806225

Abstract

N-heterocyclic carbene catalyzed synthesis of 2,2'-dihydroxybenzophenones from β-methylenals and aurones was developed. The cleavage of the C-O bond by a retro-Michael addition is the key step from the spirocyclic intermediate to final product.

Keywords: Michael addition; N-heterocyclic carbenes; aurones; catalysis; dihydroxybenzophenones.

Abstract

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