Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

Chang-An Geng; Meng-Hong Yan; Xue-Mei Zhang; Ji-Jun Chen

doi:10.1007/s13659-019-0197-y

Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay

Nat Prod Bioprospect. 2019 Apr;9(2):139-144. doi: 10.1007/s13659-019-0197-y. Epub 2019 Jan 16.

Authors

Chang-An Geng^{1

2}, Meng-Hong Yan^{1

2}, Xue-Mei Zhang^{1

2}, Ji-Jun Chen^{3

4

5}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132# Lanhei Road, Kunming, 650201, Yunnan, People's Republic of China.
² Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, People's Republic of China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132# Lanhei Road, Kunming, 650201, Yunnan, People's Republic of China. chenjj@mail.kib.ac.cn.
⁴ Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, People's Republic of China. chenjj@mail.kib.ac.cn.
⁵ University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. chenjj@mail.kib.ac.cn.

Abstract

A new flavane, bropapyriferol (1), and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay. The structure of compound 1 was determined by extensive 1D and 2D NMR, [α]_D spectroscopic data and quantum computation. Daphnegiravan F (2) and 5,7,3',4'-tetrahydroxy-3-methoxy-8,5'-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro. Especially, compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis (MIC = 1.95 ppm) than the positive control, triclosan.

Keywords: Anti-oral microbial activity; Bropapyriferol; Broussonetia papyrifera.

Abstract

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