Taming autoimmunity: Translating antigen-specific approaches to induce immune tolerance

José M Carballido; Pere Santamaria

doi:10.1084/jem.20182287

Taming autoimmunity: Translating antigen-specific approaches to induce immune tolerance

J Exp Med. 2019 Feb 4;216(2):247-250. doi: 10.1084/jem.20182287. Epub 2019 Jan 16.

Authors

José M Carballido¹, Pere Santamaria^{2

3}

Affiliations

¹ Novartis Institutes for BioMedical Research, Basel, Switzerland jose.carballido@novartis.com.
² Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada psantama@ucalgary.ca.
³ Institut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

Abstract

José M. Carballido, Executive Director at Novartis Institutes for BioMedical Research, and Pere Santamaria, Professor of Immunology at the University of Calgary and Founder of Parvus Therapeutics Inc., discuss the opportunities and challenges of translating antigen-specific approaches for autoimmunity with an emphasis on the need for scientific rigor in the preclinical stage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens*
Autoimmunity*
Humans
Immune Tolerance*

Substances

Antigens

Grants and funding

CIHR/Canada