Targeting mutant estrogen receptors

Elife. 2019 Jan 16:8:e44181. doi: 10.7554/eLife.44181.

Abstract

A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.

Keywords: SERM/SERD; acquired drug resistance; bazedoxifene; breast cancer; cancer biology; estrogen receptor; hormone therapy; human.

MeSH terms

  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / genetics
  • Female
  • Humans
  • Mutant Proteins / metabolism*
  • Mutation / genetics
  • Receptors, Estrogen / genetics*
  • Selective Estrogen Receptor Modulators / pharmacology
  • Selective Estrogen Receptor Modulators / therapeutic use

Substances

  • Mutant Proteins
  • Receptors, Estrogen
  • Selective Estrogen Receptor Modulators