Abstract
A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.
Keywords:
SERM/SERD; acquired drug resistance; bazedoxifene; breast cancer; cancer biology; estrogen receptor; hormone therapy; human.
© 2019, Wardell et al.
MeSH terms
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Breast Neoplasms / drug therapy
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Breast Neoplasms / genetics
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Female
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Humans
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Mutant Proteins / metabolism*
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Mutation / genetics
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Receptors, Estrogen / genetics*
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Selective Estrogen Receptor Modulators / pharmacology
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Selective Estrogen Receptor Modulators / therapeutic use
Substances
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Mutant Proteins
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Receptors, Estrogen
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Selective Estrogen Receptor Modulators