A mosaic of old and young nucleoporins

Takeshi Shimi; Hiroshi Kimura

doi:10.1083/jcb.201811170

A mosaic of old and young nucleoporins

J Cell Biol. 2019 Feb 4;218(2):385-386. doi: 10.1083/jcb.201811170. Epub 2019 Jan 15.

Authors

Takeshi Shimi¹, Hiroshi Kimura²

Affiliations

¹ Cell Biology Center and World Research Hub Initiative, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.
² Cell Biology Center and World Research Hub Initiative, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan hkimura@bio.titech.ac.jp.

Abstract

Some nucleoporins, the nuclear pore complex (NPC) components, have exceptionally long lifetimes. In this issue, Toyama et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201809123) report that NPCs are maintained by a slow piecemeal replacement of NPC components in dividing and terminally differentiated cells and by whole-pore exchange in quiescent cells.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Nucleus
Mosaicism*
Nuclear Pore
Nuclear Pore Complex Proteins / genetics*

Substances

Nuclear Pore Complex Proteins