Tumor Extracellular Vesicles Impede Interferon Alert Responses

Candia M Kenific; Gang Wang; David Lyden

doi:10.1016/j.ccell.2018.12.006

Tumor Extracellular Vesicles Impede Interferon Alert Responses

Cancer Cell. 2019 Jan 14;35(1):3-5. doi: 10.1016/j.ccell.2018.12.006.

Authors

Candia M Kenific¹, Gang Wang¹, David Lyden²

Affiliations

¹ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
² Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: dcl2001@med.cornell.edu.

PMID: 30645974
DOI: 10.1016/j.ccell.2018.12.006

Abstract

Tumor-derived extracellular vesicles promote metastasis by inducing functional changes in cells at pre-metastatic sites conducive for tumor cell colonization. In this issue of Cancer Cell, Ortiz and colleagues show that type I interferon regulates extracellular vesicle uptake and that modulating this pathway holds promise for treating metastasis.

Publication types

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MeSH terms

Extracellular Vesicles*
Humans
Interferons
Neoplasms*
Oxysterols*

Substances

Oxysterols
Interferons