Use of a personalized phenytoin dosing approach to manage difficult to control seizures in an infant with a SCN2A mutation

Eur J Clin Pharmacol. 2019 May;75(5):737-739. doi: 10.1007/s00228-019-02629-w. Epub 2019 Jan 15.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Administration, Intravenous
  • Dose-Response Relationship, Drug
  • Electroencephalography
  • Female
  • Humans
  • Infant, Newborn
  • Mutation, Missense
  • NAV1.2 Voltage-Gated Sodium Channel / genetics*
  • NAV1.2 Voltage-Gated Sodium Channel / metabolism
  • Phenytoin / administration & dosage*
  • Phenytoin / pharmacokinetics
  • Precision Medicine / methods
  • Seizures / diagnosis
  • Seizures / drug therapy*
  • Seizures / genetics
  • Treatment Outcome
  • Voltage-Gated Sodium Channel Blockers / administration & dosage*
  • Voltage-Gated Sodium Channel Blockers / pharmacokinetics

Substances

  • NAV1.2 Voltage-Gated Sodium Channel
  • SCN2A protein, human
  • Voltage-Gated Sodium Channel Blockers
  • Phenytoin