No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity

Yasmin G Hernandez-Barco; Nabeel Bardeesy; David T Ting

doi:10.1158/1078-0432.CCR-18-3877

No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity

Clin Cancer Res. 2019 Apr 1;25(7):2027-2029. doi: 10.1158/1078-0432.CCR-18-3877. Epub 2019 Jan 14.

Authors

Yasmin G Hernandez-Barco^{1

2}, Nabeel Bardeesy¹, David T Ting³

Affiliations

¹ Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
² Massachusetts General Hospital Division of Gastroenterology, Harvard Medical School, Boston, Massachusetts.
³ Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. dting1@mgh.harvard.edu.

Abstract

Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic cancer precursor lesion with established genetic features, but the cellular ecosystem of these tumors remains to be fully characterized. This study utilizes single-cell RNA sequencing to describe the dynamic landscape of epithelial, immune, and stromal cells during IPMN progression to invasive cancer.See related article by Bernard et al., p. 2194.

Publication types

Comment

MeSH terms

Adenocarcinoma, Mucinous*
Carcinoma, Pancreatic Ductal*
Disease Progression
Gastrointestinal Neoplasms*
Humans
Pancreatic Neoplasms*

Abstract

Publication types

MeSH terms

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