Clinical characterization of anti-GQ1b antibody syndrome in Korean children

J Neuroimmunol. 2019 May 15:330:170-173. doi: 10.1016/j.jneuroim.2019.01.003. Epub 2019 Jan 8.

Abstract

Anti-GQ1b antibody syndrome encompasses Miller Fisher syndrome and its related disorders. We retrospectively identified 11 pediatric patients (5.4-18 years old) with anti-GQ1b antibody syndrome. Diagnoses of patients included acute ophthalmoparesis (n = 6), classical Miller Fisher syndrome (n = 2), Miller Fisher syndrome/Guillain-Barré syndrome (n = 1), acute ataxic neuropathy (n = 1), and pharyngeal-cervical-brachial weakness (n = 1). Nine patients (81.8%) fully recovered. Maturational change in GQ1b antigen expression and the accessibility of anti-GQ1b antibodies might be the cause of the difference of clinical manifestations in children with anti-GQ1b antibody syndrome.

Keywords: Antibody; Gangliosides; Miller Fisher syndrome; Ophthalmoparesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Autoantibodies / blood*
  • Child
  • Child, Preschool
  • Female
  • Gangliosides / blood*
  • Humans
  • Male
  • Miller Fisher Syndrome / blood*
  • Miller Fisher Syndrome / diagnostic imaging
  • Miller Fisher Syndrome / epidemiology*
  • Ophthalmoplegia / blood*
  • Ophthalmoplegia / diagnostic imaging
  • Ophthalmoplegia / epidemiology*
  • Republic of Korea / epidemiology
  • Retrospective Studies
  • Syndrome

Substances

  • Autoantibodies
  • Gangliosides
  • GQ1b ganglioside