Single Exhale Biomarker Breathalyzer

Sensors (Basel). 2019 Jan 11;19(2):270. doi: 10.3390/s19020270.

Abstract

A single exhale breathalyzer comprises a gas sensor that satisfies the following stringent conditions: high sensitivity to the target gas, high selectivity, stable response over extended period of time and fast response. Breathalyzer implementation includes a front-end circuit matching the sensitivity of the sensor that provides the readout of the sensor signal. We present here the characterization study of the response stability and response time of a selective Nitric Oxide (NO) sensor using designed data acquisition system that also serves as a foundation for the design of wireless handheld prototype. The experimental results with the described sensor and data acquisition system demonstrate stable response to NO concentration of 200 ppb over the period of two weeks. The experiments with different injection and retraction times of the sensor exposure to constant NO concentration show a fast response time of the sensor (on the order of 15 s) and the adequate recovery time (on the order of 3 min) demonstrating suitability for the single exhale breathalyzer.

Keywords: biomarker detection; breath analysis device; metal-oxide gas sensor.

MeSH terms

  • Biomarkers / analysis
  • Biosensing Techniques / instrumentation*
  • Breath Tests / instrumentation*
  • Exhalation / physiology
  • Humans
  • Nitric Oxide / isolation & purification*
  • Wireless Technology / instrumentation*

Substances

  • Biomarkers
  • Nitric Oxide