Non-HDL cholesterol predictive factor of type 2 diabetes in the city of Tlemcen

Abstract

Background: type 2 diabetes mellitus (T2DM) is associated with disorders of lipoprotein metabolism mixed dyslipidemia. The purpose of this study is to verify whether non high density lipoprotein cholesterol (non-HDL-C) can contribute to the development of T2DM in a population in the extreme western Algeria.

Methods: The study was conducted in Tlemcen region on a sample of 1852 subjects,1059 with T2DM and 793 controls, these were evaluated for biochemical parameters, measured using standard enzyme procedures (SFBC or IFCC recommendations) on the Beckman CX7^® PLC (Beckman-Coulter^®, NY, USA). All the information related to the disease were collected from the patients and recorded using predesigned questionnaire.

Results: The logistic model retained, the two levels of non-HDL-C: 130 mg/dl < non-HDL-C≤160 mg/dl (OR = 0,69; 95% CI = 0,49-0,97, P = 0,033) and non-HDL-C>190 mg/dl (OR = 2,22; 95% CI = 1,31-3,76, P = 0,003), inbreeding (OR = 1,71; 95% CI = 1,44-2,04, P = 0,000) and the two age groups 60-70 years (OR = 2,14; 95% CI = 1,47-3,1, P ≪ 0,001) and 70 years and over (OR = 2,26; 95% CI = 1,51-3,38, P ≪ 0,001).

Conclusions: The logistic model shows that non-HDL-C contributes to the development of type 2 diabetes in our population.

Keywords: Logistic model; Non-HDL-C; Type 2 diabetes mellitus; Western Algeria.