Neuromodulatory treatments for post-traumatic stress disorder (PTSD)

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8:92:148-160. doi: 10.1016/j.pnpbp.2019.01.004. Epub 2019 Jan 11.

Abstract

Electroconvulsive therapy has been used successfully in some individuals with posttraumatic stress disorder (PTSD) whose symptoms have not improved with other treatments. But there are only a few reports. Meanwhile, an array of new neuromodulation strategies, including repetitive transcranial magnetic stimulation, transcranial direct current stimulation, vagus nerve stimulation, trigeminal nerve stimulation, and deep brain stimulation have been developed and applied experimentally in the treatment of other psychiatric disorders. This article will review the clinical evidence and mechanistic basis for their use in PTSD.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / physiopathology
  • Electric Stimulation Therapy* / methods
  • Humans
  • Stress Disorders, Post-Traumatic / physiopathology
  • Stress Disorders, Post-Traumatic / therapy*