Losartan fails to suppress epileptiform activity in brain slices from resected tissues of patients with drug resistant epilepsy

J Neurol Sci. 2019 Feb 15:397:169-171. doi: 10.1016/j.jns.2019.01.008. Epub 2019 Jan 8.

Authors

Selvin Z Reyes-Garcia¹, Carla A Scorza², Nancy N Ortiz-Villatoro², Esper A Cavalheiro²

Affiliations

¹ Disciplina de Neurociência, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil; Departamento de Ciencias Morfológicas, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras. Electronic address: selvin.reyes@unah.edu.hn.
² Disciplina de Neurociência, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

PMID: 30640154
DOI: 10.1016/j.jns.2019.01.008

No abstract available

Keywords: AT1 receptor antagonist; Human; In vitro, Electrophysiology; Temporal lobe Epilepsy.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin II Type 1 Receptor Blockers / pharmacology*
Drug Resistant Epilepsy / physiopathology*
Female
Hippocampus / drug effects*
Hippocampus / physiopathology
Humans
Losartan / pharmacology*
Male

Substances

Angiotensin II Type 1 Receptor Blockers
Losartan