Pulmonary arterial hypertension associated with interferon-beta treatment for multiple sclerosis. Case report and literature review

Mult Scler Relat Disord. 2019 Feb:28:273-275. doi: 10.1016/j.msard.2019.01.018. Epub 2019 Jan 6.

Abstract

Drug-Induced Pulmonary Arterial Hypertension (PAH) represents a well-known entity, predominantly related to anorexigens. Interferon-β (IFN) is considered to be a drug with a possible risk of inducing PAH. We report a patient with Multiple Sclerosis treated with IFN-β who diagnosed with PAH and her course of disease under specific PAH drug therapy. A review of the literature in IFN-β-induced PAH is provided.

Keywords: Interferon-β; Multiple sclerosis; Pulmonary arterial hypertension.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Female
  • Humans
  • Hypertension, Pulmonary / diagnosis
  • Hypertension, Pulmonary / drug therapy
  • Hypertension, Pulmonary / etiology*
  • Immunologic Factors / adverse effects*
  • Immunologic Factors / therapeutic use
  • Interferon-beta / adverse effects*
  • Interferon-beta / therapeutic use
  • Multiple Sclerosis / therapy*

Substances

  • Immunologic Factors
  • Interferon-beta