Short Communication: Viral Genetic Linkage Analysis Among Black Men Who Have Sex With Men (HIV Prevention Trials Network 061)

Julia Kobe; Octavious Talbot; Iris Chen; Susan H Eshleman; Vanessa Cummings; Darrell Wheeler; Kenneth H Mayer; Victor DeGruttola

doi:10.1089/AID.2018.0204

Short Communication: Viral Genetic Linkage Analysis Among Black Men Who Have Sex With Men (HIV Prevention Trials Network 061)

AIDS Res Hum Retroviruses. 2019 May;35(5):434-436. doi: 10.1089/AID.2018.0204. Epub 2019 Mar 18.

Authors

Julia Kobe¹, Octavious Talbot², Iris Chen³, Susan H Eshleman³, Vanessa Cummings³, Darrell Wheeler⁴, Kenneth H Mayer^{1

5}, Victor DeGruttola²

Affiliations

¹ 1 The Fenway Institute of Fenway Health, Harvard Medical School, Boston, Massachusetts.
² 2 Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
³ 3 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
⁴ 4 University at Albany-State University of New York, Albany, New York.
⁵ 5 Harvard Medical School, Boston, Massachusetts.

Abstract

Analysis of viral genetic linkage can reveal generalized transmission patterns within a population. The HIV Prevention Trials Network 061 study evaluated HIV incidence among black men who have sex with men. HIV genotypes from 169 men who were HIV infected at enrollment and 23 men who seroconverted during the study were analyzed for genetic linkage. This analysis showed some associations of viral linkage with income, study site, and timing of infection.

Keywords: HIV genetics; HIV in men who have sex with men; HIV transmission; disparities in HIV.

Publication types

Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural

MeSH terms

Black or African American*
Genetic Linkage*
Genotype
HIV / genetics*
HIV Infections / epidemiology*
HIV Infections / ethnology
Homosexuality, Male*
Humans
Male
Phylogeny
United States / epidemiology

Abstract

Publication types

MeSH terms

Grants and funding