To fully understand the brain injury mechanism and develop effective protective approaches, an accurate constitutive model of brain tissue is firstly required. Generally, the brain tissue is regarded as a kind of viscoelastic material and is simply used in the simulation of brain injury. In fact, the brain tissue has the behavior of the visco-hyperelastic property. Therefore, this paper presents an effective computational inverse method to determine the material parameters of visco-hyperelastic constitutive model of brain white matter through compression experiments. First, with the help of 3D hand scanner, 3D geometries of brain white matter specimens are obtained to make it possible to establish the accurate simulation models of the specific specimens. Then, the global sensitivity analysis is adopted to evaluate the importance of the material parameters and further determine the parameters which may be identified. Subsequently, based on the genetic algorithm, the optimal material parameters of brain white matter can be identified by minimizing the match error between the experimental and simulated responses. Finally, by comparing the experiment and simulation results on the other specific specimen, and the simulation results with the material parameters from the references, respectively, the accuracy and reliability of the constitutive model parameters of brain white matter are demonstrated. Graphical abstract The main flowchart of the computational inverse technique for determining the material parameters of specimen-specific on brain white matter. Generalization: Combining the computational inverse method and unconfined uniaxial compression experiment of the specific specimen, an effective identification method is presented to accurately determine the hyperelastic and viscoelastic parameters of brain white matter in this paper.
Keywords: Brain white matter; Computational inverse method; Global sensitivity analysis; Material parameter identification; Visco-hyperelastic.