Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets

Tissue Eng Part C Methods. 2019 Feb;25(2):71-81. doi: 10.1089/ten.TEC.2018.0336.

Abstract

This research deals with finding a proper bioengineering strategy to improve the outcome of islets transplantation for treatment of type 1 diabetes. It is focused on the mimicking of islet extracellular matrix niche in microwell islet delivery devices to improve their endocrine function.

Keywords: ECM; insulin secretion; islet function; microwell scaffolds; type 1 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bioengineering
  • Cells, Cultured
  • Collagen Type IV / chemistry
  • Collagen Type IV / metabolism*
  • Extracellular Matrix / chemistry
  • Extracellular Matrix / metabolism*
  • Female
  • Glucose / pharmacology*
  • Humans
  • Insulin Secretion / drug effects*
  • Islets of Langerhans / cytology*
  • Islets of Langerhans / drug effects
  • Islets of Langerhans / metabolism
  • Laminin / chemistry
  • Laminin / metabolism*
  • Male
  • Polyesters / chemistry
  • Polyesters / metabolism
  • Polyurethanes / chemistry
  • Polyurethanes / metabolism
  • Sweetening Agents / pharmacology
  • Tissue Scaffolds*

Substances

  • COL4A1 protein, human
  • Collagen Type IV
  • Laminin
  • Polyesters
  • Polyurethanes
  • Sweetening Agents
  • microthane foam
  • Glucose