Abstract
This research deals with finding a proper bioengineering strategy to improve the outcome of islets transplantation for treatment of type 1 diabetes. It is focused on the mimicking of islet extracellular matrix niche in microwell islet delivery devices to improve their endocrine function.
Keywords:
ECM; insulin secretion; islet function; microwell scaffolds; type 1 diabetes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Bioengineering
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Cells, Cultured
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Collagen Type IV / chemistry
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Collagen Type IV / metabolism*
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Extracellular Matrix / chemistry
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Extracellular Matrix / metabolism*
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Female
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Glucose / pharmacology*
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Humans
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Insulin Secretion / drug effects*
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Islets of Langerhans / cytology*
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Islets of Langerhans / drug effects
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Islets of Langerhans / metabolism
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Laminin / chemistry
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Laminin / metabolism*
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Male
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Polyesters / chemistry
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Polyesters / metabolism
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Polyurethanes / chemistry
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Polyurethanes / metabolism
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Sweetening Agents / pharmacology
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Tissue Scaffolds*
Substances
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COL4A1 protein, human
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Collagen Type IV
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Laminin
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Polyesters
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Polyurethanes
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Sweetening Agents
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microthane foam
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Glucose