The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Courtney L Luterbach; Ashley Boshe; Heather I Henderson; Eric Cober; Sandra S Richter; Robert A Salata; Robert C Kalayjian; Richard R Watkins; Andrea M Hujer; Kristine M Hujer; Susan D Rudin; T Nicholas Domitrovic; Yohei Doi; Keith S Kaye; Scott Evans; Vance G Fowler Jr; Robert A Bonomo; David van Duin

doi:10.1093/ofid/ofy351

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Open Forum Infect Dis. 2018 Dec 14;6(1):ofy351. doi: 10.1093/ofid/ofy351. eCollection 2019 Jan.

Authors

Courtney L Luterbach¹, Ashley Boshe¹, Heather I Henderson¹, Eric Cober², Sandra S Richter³, Robert A Salata⁴, Robert C Kalayjian⁵, Richard R Watkins^{6

7}, Andrea M Hujer^{4

8}, Kristine M Hujer^{4

8}, Susan D Rudin^{4

8}, T Nicholas Domitrovic^{4

8}, Yohei Doi⁹, Keith S Kaye¹⁰, Scott Evans¹¹, Vance G Fowler Jr^{12

13}, Robert A Bonomo^{4

8

14

15

16}, David van Duin^{1

17}

Affiliations

¹ Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina.
² Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio.
³ Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio.
⁴ Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
⁵ Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio.
⁶ Department of Internal Medicine, Northeast Ohio Medical University, Rootstown, Ohio.
⁷ Division of Infectious Diseases, Akron General Medical Center, Akron, Ohio.
⁸ Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio.
⁹ Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
¹⁰ Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan.
¹¹ The Biostatistics Center, The George Washington University, Rockville, Maryland.
¹² Division of Infectious Diseases, Duke University, Durham, North Carolina.
¹³ Duke Clinical Research Institute, Duke University, Durham, North Carolina.
¹⁴ Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio.
¹⁵ Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio.
¹⁶ CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio.
¹⁷ Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina.

Abstract

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.

Keywords: Klebsiella pneumonia; antimicrobial resistance; carbapenem-resistant Enterobacteriaceae; trimethoprim-sulfamethoxazole; urinary tract infection.

Abstract

Grants and funding