Crossing the Mucosal Barrier: A Commensal Bacterium Gives Dengue Virus a Leg-Up in the Mosquito Midgut

Pascal Miesen; Ronald P van Rij

doi:10.1016/j.chom.2018.12.009

Crossing the Mucosal Barrier: A Commensal Bacterium Gives Dengue Virus a Leg-Up in the Mosquito Midgut

Cell Host Microbe. 2019 Jan 9;25(1):1-2. doi: 10.1016/j.chom.2018.12.009.

Authors

Pascal Miesen¹, Ronald P van Rij²

Affiliations

¹ Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.
² Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands. Electronic address: ronald.vanrij@radboudumc.nl.

PMID: 30629911
DOI: 10.1016/j.chom.2018.12.009

Abstract

Commensal bacteria that colonize the midgut of Aedes aegypti mosquitoes can influence the transmission of arthropod-borne viruses. In this issue of Cell Host & Microbe, Wu et al. (2019) show that Serratia marcescens bacteria secrete enhancin proteins that cleave membrane-bound mucins, thereby facilitating dengue virus infection of midgut epithelial cells.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Aedes / virology*
Animals
Arboviruses*
Dengue Virus*
Permissiveness
Serratia marcescens