Target populations: Adults with solid brain metastases who have not experienced a seizure.
Question 1: Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain metastases who are otherwise seizure-free?
Recommendation: Level 3: Prophylactic AEDs are not recommended for patients with brain metastases who did not undergo surgical resection and are otherwise seizure-free.
Question 2: Do prophylactic AEDs decrease the risk of seizures in patients with brain metastases and no prior history of seizures in the postoperative setting?
Recommendation: Level 3: Routine postcraniotomy AED use for seizure-free patients with brain metastases is not recommended.The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatment-adults-metastatic-brain-tumors/chapter_8.
Keywords: Antiepileptic drugs; Cerebral metastases; Craniotomy; Seizure.
Copyright © 2019 by the Congress of Neurological Surgeons.